Mohammed Namadi Sambo was born on the 2nd of August, 1954 in Zaria, Kaduna State of Nigeria. He started his Educational Career between the year 1959 at Baptist Primary School, Kakuri, Kaduna, Kobi Primary School in Bauchi and Towns School No. 1 in Zaria. Between 1967 to 1971, he attended Government Secondary School now Alhuda-Huda College in Zaria. He attended the School of Basic Studies at the Ahmadu Bello University, Zaria in 1972, after which he gained admission into the famous Department of Architecture, Ahmadu Bello University, Zaria 1973 and graduated in 1976 with Bachelor of Science degree with Honours in Architecture (B. Sc. (Hons) and holds a Masters degree (M. Sc.) Arch 1978. He served with the Oyo State Ministry of Works and Housing for the National Youth Service Corps up to August1979.
In 1988 he was appointed Honourable Commissioner for Works, Transport and Housing, Kaduna. In 1990, Namadi Sambo left the service of Kaduna State Government and went back to his private practiceIn May 2007,
Mohammed Namadi Sambo assumed office of the Governor of Kaduna State, Nigeria. His term ended on 18 May 2010. Sambo had an 11-point agenda as Governor of Kaduna State. He once proclaimed "Our 11 - point Agenda will address all the development and social needs of Kaduna state and bring tools of empowerment to youth and women in the state. Operation Yaki is meant to address the issue of security and our e-government strategy will uplift the state economically. I wish to reaffirm my total commitment to the service, Welfare and interest of the people of Kaduna State. We shall spare no effort to make sure that our tenure brings succour and prosperity to our people".
Mid way to his term as governor, he was tapped by the president of Nigeria to become his deputy,following the death of President Umaru Yar'Adua, Goodluck Jonathan became the President. Jonathan nominated Sambo as Vice President of the Federal Republic of Nigeria and his official correspondence conveying the nomination of Sambo for the VP position was received by the National Assembly on Friday 15th May 2010. On 18th of May 2010, the National Assembly approved President Goodluck Jonathan's nomination of former Kaduna State governor, Namadi Sambo, an architect, for the position of Vice President
On 19th May 2010, Namadi Sambo was formally sworn in as the Vice President of the Federal Republic of Nigeria.